Various LCMS systems are used today, such as LCMS single quadrupole system, LCMS/MS triple quadrupole system and LC quadrupole time of flight, abbreviated as LCQTOF system, and so on. This video introduces the features, advantages and applications in solving analytical problems of the different LCMS systems.
Taking sulfamerazine as an example, it explains from the ionization to mass spectra of the compound measured on the three types of LCMS. LCMS single quadrupole is used mainly for confirmation and quantitation in scan mode and/or SIM mode. LCMS/MS triple quadruple can be operated in multiple modes such as Multiple Reaction Monitoring (MRM) and product ion scan etc. due to the QqQ configuration. It is particularly important in quantitation of trace level compounds by MRM mode method. While high resolution LCQTOF provides the capability of measuring accurate masses of compounds in MS and MS/MS modes. The combination of accurate mass and MS/MS spectrum made it powerful in identification of unknown compounds and structural elucidation study.
The latest models of LCMS from Shimadzu are LCMS2050, LCMS8060NX and LCMS9050, which have a common feature – ultrafast mass spectrometry or UFMS. This unique feature benefits greatly screening analysis for many targeted or untargeted compounds such as pesticides, metabolites and toxicological compounds etc. with assistance of data analysis software.

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