Researchers have finally managed to understand the molecular mechanism in the brain that causes the surgical aesthetic and recreational drug ketamine to function as a rapid antidepressant. Traditional antidepressants work over weeks, creating new neurons, while rapid antidepressants reactivate existing connections. ThePrint’s Sandhya Ramesh explains how these drugs do this.

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Supplementary reading:

Rawat et al., Nature Communications (2022). Ketamine activates adultborn immature granule neurons to rapidly alleviate depressionlike behaviors in mice https://www.nature.com/articles/s4146...

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