Drs Jacob Sands and Jia Luo discuss NUT carcinoma, including diagnostic challenges, emerging treatments, clinical trial options, and the NUT carcinoma registry.


Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/.... The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.


Resources


NUT Carcinoma: Clinicopathologic Features, Molecular Genetics and Epigenetics https://pubmed.ncbi.nlm.nih.gov/35372...


The MYC Oncogene — The Grand Orchestrator of Cancer Growth and Immune Evasion https://pubmed.ncbi.nlm.nih.gov/34508...


SOX2 Is an Oncogenic Driver of SmallCell Lung Cancer and Promotes the Classic Neuroendocrine Subtype https://pubmed.ncbi.nlm.nih.gov/34593...


NextGeneration Sequencing in Cancer https://pubmed.ncbi.nlm.nih.gov/34408...


PET Scanning https://www.ncbi.nlm.nih.gov/books/NB...


Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma https://pubmed.ncbi.nlm.nih.gov/38154...


International NUT Carcinoma Registry https://ncregistry.org/


Automated Tumor Proportion Score Analysis for PDL1 (22C3) Expression in Lung Squamous Cell Carcinoma https://pubmed.ncbi.nlm.nih.gov/34354...


Ewing Sarcoma https://emedicine.medscape.com/articl...


Improving Lung Cancer Patient Care Through Collaboration, Psychology, and Communication https://www.medscape.com/viewarticle/...


BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications https://pubmed.ncbi.nlm.nih.gov/37049...


Testing the Safety and Efficacy of the Addition of a New Anticancer Drug, ZEN003694, to Chemotherapy Treatment (Etoposide and Cisplatin) for Adult and Pediatric Patients (1217 Years) With NUT Carcinoma https://clinicaltrials.gov/study/NCT0...


Testing the Safety and Efficacy of the Combination of Two Anticancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (1217 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors https://clinicaltrials.gov/study/NCT0...


Development of CDK4/6 Inhibitors: A Five Years Update https://pubmed.ncbi.nlm.nih.gov/33803...


A Dose Escalation and Cohort Expansion Study of KB0742 in Participants With Relapsed or Refractory Solid Tumors or NonHodgkin Lymphoma https://www.clinicaltrials.gov/search...


Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors https://clinicaltrials.gov/study/NCT0...