In Episode #243, Dr Gil Carvalho joins me to analyse a controversial new study on saturated fat, offering a definitive conclusion on what the science says.

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As we settle into 2023, there are still loose ends to reflect on and assess from last year. In today’s episode, Gil Carvalho, MD PhD returns to break down a controversial study released in late December. Focusing on saturated fats and having been well circulated online, this study positions saturated fats as a 'bogeyman' not to be feared – but how does this claim stack up against the general scientific consensus?

Gil Carvalho, MD PhD is a physician, research scientist, science communicator, speaker, and writer. He has been a member of the Genetics Society of America and the American Society for Neuroscience and has achieved accolades including a Delill Nasser Award for Professional Development in Genetics and a Mathers Foundation award. With a career spanning both medical practice and research, Dr Carvalho offers a rational, practical, and actionable perspective on this topic.

In Episode #243, we examine the aforementioned study with a researcher’s eye, breaking down analysis techniques in a way that is applicable to most scientific papers. We expand on the topic of saturated fat, reconciling the difference between cardiology guidelines and isolated studies, saturated fat, and bioindividuality. We also cover common misunderstandings, genetics, and the principles of saturated fat consumption.

Specifically, we discuss:

00:00 Intro
17:20 Saturated fat misunderstandings: Is saturated fat bad?
22:07 Principle 1: Dose matters? — How much saturated fat is too much?
30:12 Is no saturated fat the goal?
31:54 Principle 2: Replacement nutrient matters
45:53 Principle 3: Source matters
50:48 Mechanisms: Saturated fat and heart disease
55:47 Saturated fats and genetics
59:40 Target ApoB level
1:03:02 Importance of lifetime exposure
1:08:53 Statins and heart disease risk: Are statins bad for you?
1:10:52 Mendelian randomization studies
1:15:59 The totality of evidence
1:17:46 Saturated fats and total mortality
1:19:51 Saturated fat and liver health
1:20:43 Gaps in the research
1:23:52 Common arguments against lowering saturated fat
1:38:36 Outro

It was great to have Dr Carvalho back on the show to round out what the science says about saturated fat. Dr Carvalho’s communication style balances evidence with accessibility, and I hope you found this episode clarifying and useful.

Connect with Dr Gil Carvalho
• YouTube    / @nutritionmadesimple  
• Twitter   / nutritionmades3  
• Facebook   / drgilcarvalho  
• Our previous conversation in Episode #207 https://theproof.com/makingsenseof...

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Enjoy, friends.

Simon

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