In Episode 233, I’m joined by Dr Richard Johnson to examine how diet affects the health and function of metabolism and the liver.

Visit The Proof website for supporting studies and the full show notes
https://theproof.com/podcast/'>https://theproof.com/podcast/

After Dr Johnson’s appearance on [Episode #215](https://theproof.com/isfructosedriv..., listeners of The Proof had many more questions. Most of the feedback I received welcomed the opportunity for discourse with someone whose views don’t align exactly with mine, helping to disrupt the echo chamber it is easy to find ourselves in. In today’s episode, we continue to explore Dr Johnson’s position, navigating where we agree and where our stances might differ.

Dr Richard Johnson is a Professor of Medicine at the University of Colorado. He is a clinician, educator, and researcher, and has been at the forefront of obesity and diabetes research for more than 20 years. He takes special interest in the role of sugar (especially fructose) and uric acid, and has been extensively cited from his publications in top medical journals.

In Episode 233, we fill in some gaps from Dr Johnson’s past episode and explore new areas. We discuss human outcome data, animal and mechanistic data, and gaps in current studies. We also cover the role of the liver, how the diet affects its health and function, and the effect this has on metabolic health and risk of disease.

Specifically, we discuss:

0:00 Intro
3:27 Dr. Johnson’s Thesis on Fructose
11:28 Gaps in Current Studies
20:20 Saturated Fat Versus Sugar
33:09 Longterm risk of Keto Diet
36:28 Fructose Effect on Saturated Fat
40:40 Survival Mechanisms
46:37 Type of Fat
53:00 Metabolic Health & Fructose
1:02:20 Role of the Liver
1:09:15 Problem with High Blood Sugar
1:17:22 Triglycerides & Uric Acid
1:27:52 When Fatty Liver Happens
1:31:45 Ceramides
1:33:30 Outro

It is a pleasure to have Dr Richard Johnson back on the show to examine the evidence and its significance. I appreciate Richard’s time and passion for this space as we navigate where we agree and where our stances might differ. I hope this episode helped you make more educated food choices.

Connect with Dr Richard Johnson:
• Instagram:   / drrichardjjohnson  
• Twitter:   / richardjjohns11  
• Website: https://drrichardjohnson.com/
• His book, "Nature Wants Us To Be Fat": https://benbellabooks.com/shop/nature...
• Episode 215 with Richard Johnson: https://theproof.com/isfructosedriv...

The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit http://theproof.com/friends

Enjoy, friends.

Simon



Supporting studies

• Effects of shortterm overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men [PMID: 20483648] https://pubmed.ncbi.nlm.nih.gov/20483...
• Fouryear followup after twoyear dietary interventions • [PMID: 23034044] https://pubmed.ncbi.nlm.nih.gov/23034...
• Intrahepatic Fat and Postprandial Glycemia Increase After Consumption of a Diet Enriched in Saturated Fat Compared With Free Sugars [PMID: 32165444] https://pubmed.ncbi.nlm.nih.gov/32165...
• No difference between highfructose and highglucose diets on liver triacylglycerol or biochemistry in healthy overweight men [PMID: 23872500] https://pubmed.ncbi.nlm.nih.gov/23872...
• Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake • [PMID: 21489572] https://pubmed.ncbi.nlm.nih.gov/21489...





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The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit https://theproof.com/friends/.

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