This video focuses on the serotonin receptors and their molecular biology, pharmacology, and psychological effects when stimulated.

Serotonin (also known as 5hydroxytryptamine or 5HT) is a neurotransmitter molecule used in a huge variety of neurobiological processes. There are 14 different 5HT receptors in the brain and body, each with a fairly unique intracellular signaling mechanism and distinct psychological effects.

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This is the first in a miniseries on the neurobiology of the serotonin system. Link to the rest of the serotonin videos:    • Serotonin Miniseries  

Chapters:
00:00 Serotonin (5HT) is NOT just the happiness molecule
00:35 The goals and approach of this video and miniseries on serotonin
01:36 This is a new style for Sense of Mind’s neuroscience videos
02:18 Part 1: Mechanism of serotonin synaptic transmission
03:05 How SSRIs work
03:28 The “needtoknow” of synaptic transmission
03:57 Serotonin is a “neuromodulator” that can work extra synaptically
04:44 Part 2: Families and subtypes of 5HT receptors
05:20 Most 5HT receptors are GPCRs
06:00 5HT1 and 5 receptor inhibitory mechanisms
06:30 5HT2, 4, 6, and 7 receptors excitatory mechanisms
07:02 5HT3 receptor excitatory mechanism
07:33 Please sign up for the video newsletter and podcast!
08:16 Part 3: What do the different receptors do to the brain?
09:28 Some effects of stimulating 5HT receptors in the human brain
10:28 Resolving some paradoxes of 5HT pharmacology (presynaptic receptors and biased agonism)
12:25 Examples of bodily effects of 5HT stimulation
13:10 How can one neurotransmitter do so much?
13:59 Conclusion: Some remaining questions
14:35 Please like and subscribe! Thank you!

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Sources Cited:
1. Sharp, T., & Barnes, N. M. (2020). Central 5HT receptors and their function; present and future. Neuropharmacology, 177, 108155. https://pubmed.ncbi.nlm.nih.gov/32522...
2. Di Giovanni, G., & De Deurwaerdère, P. (2020). Serotonin research: Crossing scales and boundaries. https://doi.org/10.1016/j.neuropharm....
3. Hoyer, D. (2020). Targeting the 5HT system: Potential side effects. Neuropharmacology, 108233. https://pubmed.ncbi.nlm.nih.gov/32805...
4. Mosienko, V., Bader, M., & Alenina, N. (2020). The serotoninfree brain: behavioral consequences of Tph2 deficiency in animal models. In Handbook of Behavioral Neuroscience (Vol. 31, pp. 601607). Elsevier.
5. CarhartHarris, R. L., & Nutt, D. J. (2017). Serotonin and brain function: a tale of two receptors. Journal of Psychopharmacology, 31(9), 10911120. https://pubmed.ncbi.nlm.nih.gov/28858...
6. BacquéCazenave, J., Bharatiya, R., Barrière, G., Delbecque, J. P., Bouguiyoud, N., Di Giovanni, G., ... & De Deurwaerdère, P. (2020). Serotonin in animal cognition and behavior. International journal of molecular sciences, 21(5), 1649. https://pubmed.ncbi.nlm.nih.gov/32121...
7. CarvajalOliveros, A., & Campusano, J. M. (2021). Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly?. Frontiers in Behavioral Neuroscience, 14, 262. https://www.frontiersin.org/articles/...
8. Dingman M. Know Your Brain: Raphe Nuclei. Neuroscientifically Challenged. https://neuroscientificallychallenged.... Published October 27, 2017.
9. JJ Medicine. “Serotonin and Melatonin Synthesis | Tryptophan Metabolism”    • Serotonin and Melatonin Synthesis | T...  .