Dr. Ian Chang, a Cardiology Fellow at Mayo Clinic in Rochester, MN, shares practical methods in his article appearing in the March 2019 issue of Mayo Clinic Proceedings, utilizing a screening strategy for patients who have heart failure and with potential light chain amyloidosis, a condition that offers great clinical challenges if its diagnosis is late or missed. A targeted approach of the serum free light chain assay may lead to an earlier diagnosis and treatment of this condition. Available at: https://mayocl.in/2T26xL4