Welcome to our indepth educational video on "Squamous Cell Carcinoma of the Oral Cavity | GIT Morphology." In this video, we will explore one of the most common and aggressive forms of oral cancer, squamous cell carcinoma, which accounts for over 90% of oral malignancies. This video is aimed at medical students, healthcare professionals, and anyone interested in understanding this critical health issue.

We begin by discussing the etiology and risk factors associated with oral squamous cell carcinoma. The primary risk factors include tobacco use (both smoking and smokeless forms), alcohol consumption, human papillomavirus (HPV) infection, and exposure to ultraviolet light (for lip cancers). Other contributing factors include poor oral hygiene, chronic irritation from illfitting dentures, and a diet low in fruits and vegetables.

We then move on to the clinical presentation of oral SCC. Patients may present with a variety of symptoms, including persistent sores or ulcers in the mouth that do not heal, pain or difficulty in swallowing, a lump or thickening in the cheek, and unexplained bleeding. Advanced stages may involve noticeable changes in voice, weight loss, and referred pain to the ear. It's crucial to recognize these signs early, as the prognosis significantly improves with prompt treatment.

One of the most critical sections of this video is the discussion on morphology and histopathology of squamous cell carcinoma. We explore the microscopic features that pathologists look for, including the presence of keratin pearls, intercellular bridges, and varying degrees of cellular differentiation. We also discuss the different grading systems used to classify SCC based on the degree of differentiation, which helps in prognostication and treatment planning.

Treatment options for squamous cell carcinoma of the oral cavity are also thoroughly covered. Surgical excision remains the primary treatment modality, often involving the removal of the tumor with a margin of healthy tissue to ensure complete eradication. In more advanced cases, neck dissection may be necessary to remove affected lymph nodes. Radiation therapy is frequently used, either as a primary treatment in earlystage cancers or as an adjunct to surgery in more advanced stages. Chemotherapy and targeted therapy are other options, particularly for metastatic or recurrent cancers. We discuss the indications, benefits, and side effects of each treatment modality.


The prognosis of oral squamous cell carcinoma varies based on several factors, including the tumor stage at diagnosis, the patient's overall health, and the specific location of the tumor. Earlystage cancers have a much better prognosis compared to those diagnosed at an advanced stage. We provide statistics and survival rates to give a realistic picture of the outcomes associated with different stages of the disease.

To enhance understanding, we include reallife case studies of patients diagnosed with oral squamous cell carcinoma. These stories provide valuable insights into the journey from diagnosis to treatment and recovery, highlighting the challenges faced and the triumphs achieved. Hearing from survivors can be particularly inspiring and educational for viewers.

Our video also addresses the latest advancements in research and treatment of oral squamous cell carcinoma. We explore emerging therapies, such as immunotherapy, which leverages the body's immune system to fight cancer, and precision medicine, which tailors treatment based on the genetic profile of the patient's tumor. These innovations hold promise for improving outcomes and reducing side effects associated with traditional treatments.

Thank you for watching our comprehensive guide on "Squamous Cell Carcinoma of the Oral Cavity | GIT Morphology." We hope this video has provided you with valuable knowledge and insights into this significant health issue. If you found this video helpful, please like, share, and subscribe to our channel for more educational content. Feel free to leave any questions or comments below, and we'll be happy to address them.
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