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Millions of photographers use fullframe lenses on their APSC cameras. For example, they'll get a fullframe 2470 f/2.8 lens and put it on their Canon 70D, Sony a6000, or Nikon D5600. That's almost always a bad idea, however. First, APSC cameras use less than half the image produced by fullframe lenses, so you're carrying around a lot of glass that isn't being used. Second, you're also PAYING FOR that glass that you're not using. Finally, you're capturing less than half the detail the lens is producing, so if you use the same lens with a fullframe body, you'll almost always see sharper results.
Of course, being photography, it's not always that simple. If you have to crop anyway, such as when shooting wildlife, APSC cameras with a higher pixel density will show more detail than the fullframe camera. Even without cropping, you might see sharper results if the APSC camera has more megapixels, a weaker AA filter, or a deeper depthoffield.
In this video I test several camera and lens combinations to give you the information you need to make educated buying choices.