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Testosterone from Exercise Fuels Prostate Cancer During ADT?

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Exercise Elixir For Prostate Cancer

Exercise, foods, and other lifestyle changes can increase testosterone. If you are on testosterone suppression therapy (ADT), will the increase of testosterone from exercise compromise your therapy and cause your prostate cancer to grow?

Empower your fight against cancer with personalized coaching. Explore tailored exercise and nutrition programs to reduce treatment side effects and enhance your health and quality of life at https://www.exerciseelixir.com/

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Disclaimer: The information in this video should not be used as medical advice. Always consult with your own medical professional, as they know your specific case and medical history. Exercise and nutrition cannot be used as 'alternative' therapies to cancer. They work in synergy with conventional medical procedures and medications. Please follow the advice of your medical professional.

References:
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Newton, R. U., Galvão, D. A., Spry, N., Joseph, D., Chambers, S. K., Gardiner, R. A., Wall, B. A., Bolam, K. A., & Taaffe, D. R. (2019). Exercise Mode Specificity for Preserving Spine and Hip Bone Mineral Density in Prostate Cancer Patients. Medicine and science in sports and exercise, 51(4), 607–614.

Snaterse, G., Taylor, A. E., Moll, J. M., O'Neil, D. M., Teubel, W. J., van Weerden, W. M., Arlt, W., & Hofland, J. (2023). Prostate cancer androgen biosynthesis relies solely on CYP17A1 downstream metabolites. The Journal of steroid biochemistry and molecular biology, 236, 106446. Advance online publication.

Galvão, D.A., Nosaka, K., Taaffe, D.R., Peake, J., Spry, N., Suzuki, K., Yamaya, K., McGuigan, M.R., Kristjanson, L.J., Newton, R.U., 2008. Endocrine and immune responses to resistance training in prostate cancer patients. Prostate Cancer Prostatic Dis 11, 160–165.

Tymchuk, C. N., Barnard, R. J., Ngo, T. H., & Aronson, W. J. (2002). Role of testosterone, estradiol, and insulin in diet and exerciseinduced reductions in serumstimulated prostate cancer cell growth in vitro. Nutrition and cancer, 42(1), 112–116.

Sheinboim D, Parikh S, Manich P, Markus I, Dahan S, Parikh R, et al. An exerciseinduced metabolic shield in distant organs blocks cancer progression and metastatic dissemination. Cancer Res 2022;82:4164–78.

Barnard, R.J., Ngo, T.H., Leung, P.S., Aronson, W.J., Golding, L.A., 2003. A lowfat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro. Prostate 56, 201–206.

Leung, P.S., Aronson, W.J., Ngo, T.H., Golding, L.A., Barnard, R.J., 2004. Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro. J Appl Physiol 96, 450–454.

Rundqvist, H., Augsten, M., Strömberg, A., Rullman, E., Mijwel, S., Kharaziha, P., Panaretakis, T., Gustafsson, T., Östman, A., 2013. Effect of acute exercise on prostate cancer cell growth. PLoS One 8, e67579.

Newton, R. U., Mavropalias, G., Fragala, M. S., Kraemer, W. J., Häkkinen, K., Taaffe, D. R., Spry, N., Joseph, D., & Galvão, D. A. (2021). Radiotherapy before or during androgendeprivation therapy does not blunt the exerciseinduced body composition protective effects in prostate cancer patients: A secondary analysis of two randomized controlled trials. Experimental Gerontology, 151, 111427.

Wang, Y., Jacobs, E. J., Gapstur, S. M., Maliniak, M. L., Gansler, T., McCullough, M. L., Stevens, V. L., & Patel, A. V. (2017). Recreational Physical Activity in Relation to Prostate Cancerspecific Mortality Among Men with Nonmetastatic Prostate Cancer. European urology, 72(6), 931–939.

Liu, Y., Hu, F., Li, D., Wang, F., Zhu, L., Chen, W., Ge, J., An, R., & Zhao, Y. (2011). Does physical activity reduce the risk of prostate cancer? A systematic review and metaanalysis. European urology, 60(5), 1029–1044.

Kim, J. S., Wilson, R. L., Taaffe, D. R., Galvão, D. A., Gray, E., & Newton, R. U. (2022). Myokine Expression and TumorSuppressive Effect of Serum after 12 wk of Exercise in Prostate Cancer Patients on ADT. Medicine and science in sports and exercise, 54(2), 197–205.

Zheng, A., Zhang, L., Yang, J., Yin, X., Zhang, T., Wu, X., & Ma, X. (2022). Physical activity prevents tumor metastasis through modulation of immune function. Frontiers in pharmacology, 13, 1034129.

Kim, J. S., Taaffe, D. R., Galvão, D. A., Hart, N. H., Gray, E., Ryan, C. J., Kenfield, S. A., Saad, F., & Newton, R. U. (2022). Exercise in advanced prostate cancer elevates myokine levels and suppresses invitro cell growth. Prostate cancer and prostatic diseases, 25(1), 86–92.

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