Join Dr. Chat Perche, MD, PhD, for a highspeed study session.

This video is designed so that by the time you finish watching, you'll have perfectly memorized the frequently asked exam topics.

By the end of this video, you'll have perfectly memorized about Cell cycle and Anticancer drugs.

Unlocking the points of cancer chemotherapy and the cell cycle!
In this video, I'll guide you through understanding how anticancer drugs work with the cell cycle. It's not as complex as it seems – join me as I simplify the process and make it easy to remember. #cellcycle #pharmacologylectures #cancertreatment

【Notes】
▹This video was created based on data as of January 2024, with the purpose of supporting medical students in their exam preparations.

▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited.

【Contents】
00:00 The basics of chemotherapy
00:57 cancer drugs works with the cell cycle
01:03 antimetabolites: mechanisms of action
01:56 topoisomerase inhibitor: mechanisms of action
02:44 plant alkaloids; mechanisms of action
03:21 alkylating agents: mechanisms of action
04:03 antitumor antibiotics: mechanisms of action
04:37 cell cycle specific vs. nonspecific anticancer drugs

【Reference and figure】I express my gratitude and respect for your wonderful achievements.

1. Judith A. Smith, Anuja Jhingran, 28 Principles of radiation therapy and chemotherapy in gynecologic cancer: Basic Principles, Uses, and Complications,
Editor(s): David M. Gershenson, Gretchen M. Lentz, Fidel A. Valea, Roger A. Lobo,
Comprehensive Gynecology (Eighth Edition), Elsevier, 2022, Pages 618636.e1,
ISBN 9780323653992,
https://doi.org/10.1016/B978032365....
(https://www.sciencedirect.com/science...)


2. Benjamin Izar, David P. Ryan, Bruce A. Chabner, Chapter 9 Principles of Chemotherapy,
Editor(s): Leonard L. Gunderson, Joel E. Tepper, Clinical Radiation Oncology (Fourth Edition), Elsevier, 2016, Pages 171185.e2,
ISBN 9780323240987,
https://doi.org/10.1016/B978032324....
(https://www.sciencedirect.com/science...)

3. Carmen Avendaño, J. Carlos Menéndez, Chapter 2 Antimetabolites, Editor(s): Carmen Avendaño, J. Carlos Menéndez, Medicinal Chemistry of Anticancer Drugs, Elsevier, 2008, Pages 952,
ISBN 9780444528247,
https://doi.org/10.1016/B978044452....
(https://www.sciencedirect.com/science...)

4. Pommier Y. Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789802.
doi: 10.1038/nrc1977. PMID: 16990856.

5. Lee JH, Berger JM. Cell CycleDependent Control and Roles of DNA Topoisomerase II. Genes. 2019; 10(11):859. https://doi.org/10.3390/genes10110859

6. Galal H. Elgemeie, Reham A. MohamedEzzat,　Chapter 8 Anticancer alkylating agents,　Editor(s): Galal H. Elgemeie, Reham A. MohamedEzzat,　New Strategies Targeting Cancer　Metabolism, Elsevier, 2022, Pages 393505,
ISBN 9780128217832,
https://doi.org/10.1016/B978012821....
(https://www.sciencedirect.com/science...)

7. Kelland L. The resurgence of platinumbased cancer chemotherapy. Nat Rev Cancer. 2007 Aug;7(8):57384. doi: 10.1038/nrc2167. Epub 2007 Jul 12. PMID: 17625587.

8. Han, D., Serra, R., Gorelick, N. et al. Multilayered coresheath fiber membranes for controlled drug release in the local treatment of brain tumor. Sci Rep 9, 17936 (2019). https://doi.org/10.1038/s4159801954...

9. Alberts, B. DNA replication and recombination. Nature 421, 431–435 (2003). https://doi.org/10.1038/nature01407

10. LiverTox: Clinical and Research Information on DrugInduced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012. Alkylating Agents. [Updated 2015 Mar 10]. Available from: https://www.ncbi.nlm.nih.gov/books/NB...

11. Bhattacharya, B. and Mukherjee, S. (2015) Cancer Therapy Using Antibiotics. Journal of Cancer Therapy, 6, 849858. doi: 10.4236/jct.2015.610093.

12. Abe K, Ikeda M, Ide T, Tadokoro T, Miyamoto HD, Furusawa S, Tsutsui Y, Miyake R, Ishimaru K, Watanabe M, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H. Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1dependent heme synthesis. Sci Signal. 2022 Nov;15(758): eabn8017. doi: 10.1126/scisignal.abn 8017. Epub 2022 Nov 1. PMID: 36318618.