ChemDraw Template:
https://chemistrycapital.ck.page/7a0...

In this video, I discuss palladiumcatalysed cross couplings, a key reaction in organic synthesis. This reaction is commonly used in medicinal chemistry and drug discovery to develop and produce new pharmaceuticals. I also about the discovery and history of the Stille coupling, and how it can help overcome some of the problems associated with the Suzuki reaction.

References:

Cross couplings in Drug discovery

https://www.mdpi.com/14203049/25/15/...

Eaborn Work:

https://www.sciencedirect.com/science...

Migita Work:

https://academic.oup.com/chemlett/art...

https://www.sciencedirect.com/science...

Stille work:

https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...

https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...

https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...

https://onlinelibrary.wiley.com/doi/1...

Stille Review:

https://pubs.acs.org/doi/epdf/10.1021...

In memory of Stille:

https://pubs.acs.org/doi/10.1021/ma00...

Suzuki:

https://www.tandfonline.com/doi/abs/1...

Suzuki review:

[https://www.sciencedirect.com/science... Suzuki reaction.,The products of the Suzuki coupling reaction show significant advantages,lapatinib%2C atazanavir%2C and clonazepam](https://www.sciencedirect.com/science....

Derke Lowe

https://www.science.org/content/blog...

2pyridyl problem:

https://onlinelibrary.wiley.com/doi/1...

Protodeboronation:

https://pubs.acs.org/doi/10.1021/jacs...

https://pubs.acs.org/doi/10.1021/jo50...

Synthetic Methods in Drug Discovery:

https://books.rsc.org/books/editedvo...

Patents:

https://patentscope.wipo.int/search/e...

https://patentscope.wipo.int/search/e...

VEGFR

https://pubs.acs.org/doi/10.1021/op03...

Attributions:

2010 Nobel Prize:https://en.m.wikipedia.org/wiki/File:...

Suzuki:https://en.wikipedia.org/wiki/File:No...

Eaborn photo:https://pubs.rsc.org/en/content/artic...

https://commons.wikimedia.org/wiki/Fi...

Biotage:

https://www.biotage.com/largescalep...

Merck logo:https://commons.wikimedia.org/wiki/Fi...