ChemDraw Template:
https://chemistrycapital.ck.page/7a0...
In this video, I discuss palladiumcatalysed cross couplings, a key reaction in organic synthesis. This reaction is commonly used in medicinal chemistry and drug discovery to develop and produce new pharmaceuticals. I also about the discovery and history of the Stille coupling, and how it can help overcome some of the problems associated with the Suzuki reaction.
References:
Cross couplings in Drug discovery
https://www.mdpi.com/14203049/25/15/...
Eaborn Work:
https://www.sciencedirect.com/science...
Migita Work:
https://academic.oup.com/chemlett/art...
https://www.sciencedirect.com/science...
Stille work:
https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...
https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...
https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...'>https://pubs.acs.org/doi/abs/10.1021/...
https://onlinelibrary.wiley.com/doi/1...
Stille Review:
https://pubs.acs.org/doi/epdf/10.1021...
In memory of Stille:
https://pubs.acs.org/doi/10.1021/ma00...
Suzuki:
https://www.tandfonline.com/doi/abs/1...
Suzuki review:
[https://www.sciencedirect.com/science... Suzuki reaction.,The products of the Suzuki coupling reaction show significant advantages,lapatinib%2C atazanavir%2C and clonazepam](https://www.sciencedirect.com/science....
Derke Lowe
https://www.science.org/content/blog...
2pyridyl problem:
https://onlinelibrary.wiley.com/doi/1...
Protodeboronation:
https://pubs.acs.org/doi/10.1021/jacs...
https://pubs.acs.org/doi/10.1021/jo50...
Synthetic Methods in Drug Discovery:
https://books.rsc.org/books/editedvo...
Patents:
https://patentscope.wipo.int/search/e...
https://patentscope.wipo.int/search/e...
VEGFR
https://pubs.acs.org/doi/10.1021/op03...
Attributions:
2010 Nobel Prize:https://en.m.wikipedia.org/wiki/File:...
Suzuki:https://en.wikipedia.org/wiki/File:No...
Eaborn photo:https://pubs.rsc.org/en/content/artic...
https://commons.wikimedia.org/wiki/Fi...
Biotage:
https://www.biotage.com/largescalep...
Merck logo:https://commons.wikimedia.org/wiki/Fi...