Welcome to our deep dive into Mirtazapine, a distinctive medication classified as a Noradrenergic and Specific Serotonergic Antagonist (NaSSA). In this video, Dr Sanil Rege, Consultant Psychiatrist, takes you on a journey exploring the fascinating dual effects of Mirtazapine at varying doses, shedding light on its unique action on receptor profiles and how this translates to its efficacy and tolerability in clinical practice.

Mirtazapine stands out for its ability to provide relief from anxiety, depression, and even nausea in certain medical conditions, thanks to its action on a variety of receptors, including the 5HT2A, 5HT2C, and 5HT3, as well as its histaminergic and noradrenergic activities.

At lower doses (1530 mg), Mirtazapine acts primarily through serotoninspecific antagonism, offering benefits like antianxiety effects, improved sleep quality, and no sexual dysfunction, distinguishing it from other antidepressants.

However, its antihistamine properties act as a limiting factor due to weight gain.

As we increase the dose (4560 mg), we unlock Mirtazapine’s noradrenergic effects, crucial for treating severe forms of depression through the potentiation of noradrenaline and dopamine.

Moreover, we will compare Mirtazapine with Mianserin, highlighting the reasons behind Mirtazapine's preference in clinical settings despite their similarities, including Mianserin's association with agranulocytosis.

This video is your comprehensive guide to understanding Mirtazapine's pharmacodynamics, its clinical applications, and how its receptorspecific actions contribute to its side effects and benefits at different dosages. Whether you're a healthcare professional, a student, or someone interested in the science behind psychiatric medication, join us to unravel the complexities of Mirtazapine and how it's used to combat various psychiatric and physical symptoms.

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#MirtazapineMechanisms
#NaSSAExplained
#DualDoseEffects
#MirtazapineVsMianserin
#DepressionTreatment
#AnxietyRelief
#Pharmacodynamics
#MentalHealthMedication
#SerotoninAntagonism
#NoradrenergicBoost

Key Moments:
0:00 Mirtazapine's mechanism of action and dosage effects.
1:45 Serotonin receptors and their effects on depression and other symptoms.
3:18 Mirtazapine's benefits and side effects.
4:51 Mirtazapine's effects on sedation, weight gain, and noradrenaline.
6:41 Mirtazapine's effects on serotonin and dopamine.


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