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Video reviewing calcium channel blocker (CCB) overdose and toxicity. Pharmacology, clinical manifestations, and treatment principles are discussed. Within treatment principles, the mechanism and benefit of highdose insulin is reviewed. Video created by Daniel Gergen.

References:
Jang DH. Calcium Channel Blockers. In: Nelson LS, Howland MA, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS, eds. Goldfrank's Toxicologic Emergencies, 11e. New York, NY: McGrawHill Education; 2019.

Levine M, Boyer EW, Pozner CN, et al. Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil. Crit Care Med. 2007;35(9):20712075.

StOnge M, Anseeuw K, Cantrell FL, et al. Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults. Critical care medicine. 2017;45(3):e306e315.

Smith SW, Ann Howland M. Calcium. In: Nelson LS, Howland MA, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS, eds. Goldfrank's Toxicologic Emergencies, 11e. New York, NY: McGrawHill Education; 2019.

Howland MA, Smith SW. Glucagon. In: Nelson LS, Howland MA, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS, eds. Goldfrank's Toxicologic Emergencies, 11e. New York, NY: McGrawHill Education; 2019.

Stellpflug SJ, Kerns Ii W. HighDose Insulin. In: Nelson LS, Howland MA, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS, eds. Goldfrank's Toxicologic Emergencies, 11e. New York, NY: McGrawHill Education; 2019.