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In this important keynote lecture, Drs Paul Fiorilli, Howard Herrmann & Wilson Szeto, Hospital of the University of Pennsylvania & Penn Presbyterian Medical Center, Philadelphia, discuss the burden of mitral valve disease, the rationale for transcatheter treatment, the challenges for treatment, several of the current devices under investigation, and their thoughts on the future directions of the field.

Cite this article as: Fiorilli PN, Herrmann HC, Szeto WY. Transcatheter mitral valve replacement: latest advances and future directions. Ann Cardiothorac Surg 2021;10(1):8595. doi: 10.21037/acs2020mv21

The Annals of Cardiothoracic Surgery (ACS) is a bimonthly peerreviewed scientific journal, focusing on the latest clinical evidence and surgical techniques. For more information regarding upcoming issues and manuscript submissions please visit www.annalscts.com.