Colchicine is used to prevent or treat gout attacks.

Gout is an inflammatory arthritis that is the result of the precipitation of serum urea into crystalized deposits of monosodium urea (MSU) in and around the joint.

These crystals cause sever inflammatory arthritis, which is initiated by mechanisms involving various proinflammatory mediators, such as cytokines and chemokines.


Colchicine affects the molecular pathology of gouty arthritis.
And prevents the formation of microtubules.



Colchicine interferes with the inflammatory molecules found in neutrophils and monocytes.

Colchicine binds to both α and βtubulin to create a tubulin–colchicine complex that prevents the formation of microtubules.

The state of microtubule polymerization can control numerous cellular functions, including
intracellular organelle and vesicle transport

secretion of cytokines and chemokines

and migration, division, and regulation of gene expression.

These actions influence the cell activity known to be involved in inflammatory pathways central to the pathogenesis of gout.

However, with overdose,
Colchicine becomes toxic as an extension of these mechanisms.

The adverse effects and toxicities of colchicine are

gastrointestinal upset
renal failure
neutropenia
damage bone marrow (anemia)
neuromyopathy and rhabdomyolysis
death(accidental and intentional)

(Reference) I express my gratitude and respect for your wonderful achievements.

1. Drug bank. “Colchicine” drugbank.ca

2. Dalbeth N, Lauterio TJ, Wolfe HR.
Mechanism of action of colchicine in the treatment of gout.
Clin Ther. 2014 Oct 1;36(10):146579. doi: 10.1016/j.clinthera.2014.07.017. Epub 2014 Aug 21. PMID: 25151572 DOI: 10.1016/j.clinthera.2014.07.017

3. Cronstein, B.N., Molad, Y., Reibman, J. et al. Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. J Clin Invest. 1995; 96: 994–1002

4. Yanqi Xie, Liliia M. Kril, Tianxin Yu, Wen Zhang, Mykhaylo S. Frasinyuk, Svitlana P. Bondarenko, Kostyantyn M. Kondratyuk, Elizabeth Hausman, Zachary M. Martin, Przemyslaw P. Wyrebek, Xifu Liu, Agripina Deaciuc, Linda P. Dwoskin, Jing Chen, Haining Zhu, ChangGuo Zhan, Vitaliy M. Sviripa, Jessica Blackburn, David S. Watt & Chunming Liu 
Semisynthetic aurones inhibit tubulin polymerization at the colchicinebinding site and repress PC3 tumor xenografts in nude mice and mycinduced TALL in zebrafish
Scientific Reports 9, Article number: 6439 (2019)

5. Ivana Spasevska , Ahmed T. Ayoub , Philip Winter , Jordane Preto , Gane K.S. Wong , Charles Dumontet and Jack A. Tuszynski
Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
Int. J. Mol. Sci. 2017, 18(8), 1676; https://doi.org/10.3390/ijms18081676

6. Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, DubnovRaz G, Pollak U, Koren G, Bentur Y (June 2010). "Colchicine poisoning: the dark side of an ancient drug". Clinical Toxicology. 48 (5): 407–14. doi:10.3109/15563650.2010.495348. PMID 20586571.


(Picturtes)

1. Structure of Colchicin
By Jynto (talk) Own work. This image was created with Discovery Studio Visualizer., CC0, https://commons.wikimedia.org/w/index...

2. Gout. Mayo Clinic
mayoclinic.org

3. Bobjgalindo
Spiked rods of monosodium urate crystals photographed under polarized light from a synovial fluid sample. Formation of monosodium urate crystals in the joints are associated with gout.




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