Inflammation in the heart can mount immune responses even in the absence of immune cells, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

The discovery provides clearer targets for treating myocarditis, or inflammation of the heart muscle, a condition which can develop suddenly after a viral infection, vaccination, or due to gene mutations, said Elizabeth McNally, MD, PhD, the Elizabeth J. Ward Professor of Genetic Medicine and director of the Center for Genetic Medicine, who was senior author of the study.

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