Presented By:
Dr. Brandy Gunsolus

Speaker Biography:
Dr. Brandy Gunsolus received her BS degree in Chemistry from Southeastern Louisiana University, a BS degree in Clinical Laboratory Science from LSU Health Sciences Center – New Orleans, an MS degree and Doctor of Clinical Laboratory Science degree from Rutgers University. She is currently over Pathology Utilization, is the Physician/Laboratory Liaison, oversees the Immunology and Toxicology Laboratories, and is Director of Specimen Referral at Augusta University Medical Center. She also serves on the Doctoral Review Committee for National Accreditation Agency for Clinical Laboratory Science and is the American Society for Clinical Laboratory Science National delegate to the Coalition to Improve Diagnosis in Medicine. She is Chair for the American Society for Clinical Laboratory Science National Scientific Assembly for Laboratory Administration/Industry/Consulting/Accreditation/Quality Assurance, ViceChair for the American Society for Clinical Laboratory Science National Patient Safety committee and President of the South Carolina chapter for American Society for Clinical Laboratory Science.

Webinar:
Updates on Primary Aldosteronism Screening and Use of Direct Renin

Webinar Abstract:
Primary aldosteronism (PA) is the most common form of secondary hypertension, caused by hyperactivity in one or both of the adrenal glands that leads to inappropriate aldosterone production. The prevalence of PA among general and resistant hypertensive populations ranges from 520%. PA is considered highly treatable and potentially curable. As such, the Endocrine Society guidelines recommend screening for PA in high risk populations using the plasma aldosterone/plasma renin ratio (ARR). It is generally accepted that both the plasma renin and aldosterone levels tend to fall with advancing age and plasma renin decreases more than aldosterone; consequently, the ARR increases in the elderly which supports the need for agespecific ARR cutoffs. Traditionally, renin has been measured by a plasma renin activity (PRA) radioimmunoassay or liquid chromatography tandem mass spectrometry (LCMS/MS). Direct renin concentration (DRC) immunoassays, also known as plasma renin concentration (PRC), have recently become more popular because of numerous benefits including walkaway automation, shorter turnaround times, and excellent reproducibility compared to PRA. In this webinar, we will review the key differences between PRA and DRC assays and discuss the utility of proposed agespecific ARR cutoffs for PA screening calculated using direct renin measurement.

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