Description: In this video, Dr. Steve Murray, Associate Professor and Director, Knock Out Mouse Project (KOMP) development, The Jackson Laboratory, discusses various aspects of mouse models of human genetic disease, including different types of models, mouse model resources (International Mouse Phenotyping Consortium and Mouse Genome Informatics), benefits and limitations of mouse models, and the impact of genetic context, with illustrative examples.
Date recorded: October 14th, 2021, for the ClinGen Biocurator Working Group