Venous thromboembolism (VTE) is a leading cause of death worldwide. In the Western world, someone develops a VTE every 16 seconds. Manifestations of the disease are deep vein thrombosis and pulmonary embolism, more at https://www.thrombosisadviser.com/en/...

References:
Roger VL, Gc AS, LloydJones DM, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics 2011 update: a report from the American Heart Association. Circulation. 2011;123(4):e18e209

Cohen AT, Agnelli G, Anderson FA, Arcelus JI, Bergqvist D, Brecht JG, Greer IA. Venous thromboembolism (VTE) in Europe. Thromb Haemost. 2007;98:756764 EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med. 2010;363(26):24992510