Vitamin B1Thiamin(e) DeficiencySo many symptoms!Part 1

Dr. Derrick Lonsdale
“It is a critical and ratelimiting cofactor to multiple enzymes involved in this process, including those at the entry points and at critical junctures for the glucose, fatty acid, and amino acid pathways.”

“thiamine availability dictates molecular oxygen homeostasis and mitochondrial ATP production.”

Thiamin dependent enzymes: there are more than the 5 listed.
1. Transketolase
2. Pyruvate Dehydrogenase Complex
3. 2HydroxyacylCoA Lyase
4. Branched Chain KetoAcid Dehydrogenase
5. AlphaKetoglutarate Dehydrogenase Complex

Recommended daily intake men 1.2 mg and women 1.1mg

B vitamins are watersoluble, so they dissolve quickly in the body. Half life 112 hours with approx. 30 mg stored muscle, heart, brain, liver and kidneys which can be depleted in 23 weeks. Or with acute illness it can be depleted in as little as 72 hrs. Absorbed in the jejunum of the small intestine by diffusion.

Thiamin deficiency is rare in the US but suboptimal levels are quite common. True deficiency is called Beri Beri which cause damage to nerves, muscles and cardiovascular system.
Wet beri bericardiovascular system(shortness of breath, tachycardia) and edema
Dry beri berinervous system, N/T in hands and feet, confusion, memory loss, trouble moving the legs and pain.

WernickeKorsakoff Syndromealcoholics, malabsorption, anorexia

http://www.mayoclinic.org/drugssuppl...
http://www.mayoclinic.org/drugssuppl...
https://ods.od.nih.gov/factsheets/Thi...
http://lpi.oregonstate.edu/mic/vitami...
http://umm.edu/health/medical/altmed/...
http://www.ncbi.nlm.nih.gov/books/NBK...
https://pubmed.ncbi.nlm.nih.gov/22116...
https://www.mdpi.com/20734409/10/10/...
https://www.researchgate.net/figure/B...
https://pubmed.ncbi.nlm.nih.gov/15328...

Dr. Jin Sung is a Chiropractic Physician who specializes in the management of complex chronic conditions in Massachusetts, 30 minutes north of Boston. He utilizes natural and alternative therapies to help manage complex cases such as Hashimoto's, autoimmune conditions, IBS, SIBO, chronic fatigue, brain fog, early Alzheimer's, etc.

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The content of this video is for educational purposes only and does not constitute medical advice. Please consult with your physician before embarking on any dietary changes or taking any nutritional supplements.