Definitive Evidence from MetaAnalysis and Trial Sequential Analysis

https://www.ncbi.nlm.nih.gov/pmc/arti...

(Italy)

Various studies, a association between severe vitamin D deficiency and bad COVID19 outcomes.

Vitamin D plays a crucial role in immune function and inflammation.

Recent data suggest a protective role of vitamin D against bad outcomes

Nutraceutical approach

Promote the immune response and reduce the inflammatory response

Antiinflammatory, antioxidant, and immunomodulatory properties of vitamin D

Immune optimisation and immune boosting

Vitamin D maintains pulmonary barrier function

Determines the production of antimicrobial peptides

Enhances neutrophil activity

Shifts the adaptive immune response to a more T helper cell2 type

Antiinflammatory effects of vitamin D

Reduces the production of proinflammatory cytokines,

such as IL6, IL8, IL9, IL12, TNF alfa, IFN gamma

Increases production of antiinflammatory cytokines,

such as IL4, IL5, IL10

Patients with a low baseline vitamin D, more benefit

Reduce risk of asthma exacerbations

Prevents acute respiratory infections,

and reducing their complications

COVID19 and vitamin D (CoVIVID study): a systematic review and metaanalysis of randomized controlled trials

https://www.ncbi.nlm.nih.gov/pmc/arti...

The rates of RTCR positivity were significantly decreased in the intervention group as compared to the nonvitamin D groups

(RR = 0.46)

Conclusively, COVID19 patients supplemented with vitamin D, fewer rates of ICU admission, mortality events, and RTPCR positivity.

Metaanalysis and trial sequential analysis (TSA)

Better explain the strength of association

Protective role of vitamin D supplementation,

and risk of mortality / admission to intensive care units

We searched four databases on 20 September 2022.

Screened the randomized clinical trials (RCTs)

Assessed the risk of bias

(how to adjust thresholds for significance in randomised clinical trials when the required sample size has not been reached)

The prespecified outcomes of interest

Mortality and ICU admission

78 bibliographic citations

Five RCTs were suitable for our analysis

Results

Vitamin D administration results in a decreased risk of death, 0.49

Vitamin D administration results in a decreased risk of ICU admission, 0.28

Protective role of vitamin D and ICU admission

The TSA of the protective role of vitamin D and ICU admission showed that, since the pooling of the studies reached a definite sample size, the positive association is conclusive.

The studies

Effects of a 2Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid19: A Randomized Clinical Trial

https://www.mdpi.com/20726643/13/7/2170

(Saudi)

Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID19: A pilot randomized clinical study

https://www.ncbi.nlm.nih.gov/pmc/arti...

(Spain)


Changes in the immune response against SARSCoV2 in individuals with severe COVID19 treated with high dose of vitamin D

https://www.ncbi.nlm.nih.gov/pmc/arti...

(Spain)

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID19

https://www.ncbi.nlm.nih.gov/pmc/arti...

(Brazil)

Calcifediol treatment and COVID19related outcomes

https://www.ncbi.nlm.nih.gov/pmc/arti...

(Spain)

Medicines & Healthcare products
Regulatory Agency

https://www.bmj.com/content/377/bmj.o...

86% industry funded