VonWillebrand factor (vWF) comes from the meagakaryocytes (bone marrow) as well as the WeibelPalade bodies (endothelial cells). Von Willebrand factor (vWF) helps the platelets adhere to the sub endothelial collagen via GP1b receptor on the platelet.

Von Willebrand disease (vWD) is the most common inherited bleeding disorder worldwide.

Primary hemostasis involves forming a platelet plug (thrombocytes) whereas secondary hemostasis involves making a fibrin thrombus (coagulation factors).

Ionized calcium helps blood coagulate.

We test for primary hemostasis via platelet count, bleeding time, and platelet aggregometry.
We test secondary Hemostasis via prothrombin time (PT), activated partial thromboplastin time (aPTT), and the old coagulation time (or clotting time, or thrombin time).

Von Willebrand Dusease (vWD) affects primary as well as secondary Hemostasis.

Hemolytic Uremic Syndrome (HUS), atypical Hemolytic Uremic Syndrome (aHUS), and Thrombotic Thrombocytopenic Syndrome (TTP).

Atypical hemolytic uremic syndrome (aHUS) is similar to thrombotic thrombocytopenic Purpura (TTP).

Typical Hemolytic Uremic Syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure.

Thrombotic thrombocytopenic purpura (TTP) is a pentad of microangiopathic hemolytic anemia, thrombocytopenia, acute renal failure, fever, and neurological abnormalities.

Get my AntiCancer Pharmacology Course: https://www.medicosisperfectionalis.c...

Use the Promo Code: 35OFFCANCER to get a 35% discount on any product (only 6 left).

Cardiac Pharmacology Lectures:
https://www.medicosisperfectionalis.c... ...

— Antibiotics Lectures: https://www.medicosisperfectionalis.com/'>https://www.medicosisperfectionalis.com/

BernardSoulier Syndrome (BSS) is an autosomal recessive (AR) disorder characterized by a defective GP1b platelet receptor leading to a problematic platelet adhesion process (primary hemostasis).

Glanzmann Thrombasthenia (GT) is an autosomal recessive defect in the GPIIb/IIIa (GP2b/3a) receptor on the platelet which leads to defective platelet aggregation.

Ristocetin Cofactor Assay (RIPA) is usually abnormal in cases of BernardSoulier Syndrome (BSS).
Bleeding time is prolonged, platelets are big in size, but few in number (Macrothrombocytopenia).

Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/me...

With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...

Picmonic has hundreds of animated medical mnemonics...These are very interactive Picmonics that help you memorize and retain tons of medical topics.
They also have a mobile app so that you can learn and have fun on the run.

Disclaimer: I use affiliate links...

Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).

Bleeding time (BT) is another test for platelet function.

► Get my Leukemia Notebook:
https://www.medicosisperfectionalis.c...
► Watch my hematology videos:    • Hematology/ Oncology  

► Support me on Patreon:   / medicosis  
► Support me on PayPal: https://www.paypal.me/perfectionalis/

► Join my Channel on YouTube:    / @medicosisperfectionalis  

► All of my premium courses are ON SALE: https://www.medicosisperfectionalis.com/'>https://www.medicosisperfectionalis.com/

► Watch my Cardiac Pharmacology Playlist on YouTube:    • Cardiac Pharmacology  

► Watch my Rheumatology Playlist:    • Rheumatology  

► If you have any questions, please email me at: [email protected]

► Watch the entire playlist of Rheumatology    • Rheumatology  

If you have joined my channel on youtube (the join button that's next to the subscribe button), then go to the "community tab" and you will find some memberonly posts.

Thank you so much for supporting my channel! Love ❤
Happy studying!!


Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/me... My Favorite Productivity App: https://airtable.com/invite/r/2zH40fus/'>https://airtable.com/invite/r/2zH40fus/

My favorite Productivity App: https://airtable.com/invite/r/2zH40fus/'>https://airtable.com/invite/r/2zH40fus/ Save on your mobile phone bill: http://fbuy.me/q6bMj Qbank (TrueLearn): https://truelearn.referralrock.com/l/...