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Rafael Bejar, MD, PhD, Director of the MDS Center of Excellence at the Moores Cancer Center of the University of San Diego, explains what mutations in individual genes mean for the outlook with myelodysplastic syndromes (MDS). He also discusses the use of biomarker testing to monitor and predict MDS disease course and the importance of cytogenetic analysis to look for chromosomal abnormalities affecting MDS prognosis and treatment.