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What is bioinformatics? Bioinformatics is field that uses computers, software tools, and statistics to analyze large data sets of DNA sequence information, leading to a revolution in genomics and personalized medicine. This video describes how bioinformatic tools can be used to compare genes between species, analyze mutations in the cancer genome of a specific patient, and has been used to uncover interesting new biology such as the CRISPR system. To explore more biology terms and concepts, see the BioDictionary in The Explorer’s Guide to Biology (explorebiology.org/biodictionary).