In a previous video I've talked about the way you should approach a structural imaging study (CT or MRI) in a patient suspected of suffering from dementia, about the various tools and atrophy scales you can use to help you in your approach, and the spectrum of agerelated imaging findings. In this video I'll discuss the imaging findings that can be observed in several specific demenatias.

In daily clincal and radiological practice, elderly patients often consult their GP or neurologist because they suffer from increasing forgetfullness and worry that this could be an early sign of dementia. In some patients it will be, in others it won't. Imaging studies are often not sufficient to solve that question, but provide a very important part of the dementia puzzle.

The most frequent cause of dementia is Alzheimer's disease. Alzheimer's disease is characterized by hippocampal atrophy that is already present before the disease becomes clinically manifest. As a consequence the most important region to examine will be the mesiotemporal region. When age abnormal mesiotemporal atrophy is present, it is less likely that the forgetfullness is part of "normal ageing" and a neurodegenerative diseases if present, of which Alzheimer is the most frequent (and thus the most likely). Mesiotemporal atrophy is not specific for Alzheimer's disease however, and hippocampal atrophy will eventually develop in the advanced stage of most dementia syndromes.

0:00 Start
0:54 Introduction: what is dementia?
15:18 Alzheimer Disease
26:10 Early Onset Alzhzeimer's Disease
36:28 Lewy Body Dementia
45:05 Frontotemporal Dementia
56:10 Vascular Dementia
1:10:42 CADASIL
1:15:32 Cerebral Amyloid Angiopathy (CAA)
1:21:39 CreutzfeldtJakob Disease
1:31:15 Key Messages

Next on the list: a short 30 minute version of both presentations on imaging of dementia, and a presentation of imaging in neurodegenerative movement disorders (Parkinson and beyond). Stay tuned!

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