Diabetes and Weight Loss: Why Does Type 2 Diabetes Makes Weight Loss So Challenging?

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Today, we’re exploring why losing weight is so challenging for people with type 2 diabetes. Despite new medications like Zepbound, weight management remains tough for those with this condition. Interestingly, losing weight can help manage diabetes, but diabetes itself makes it harder.

In the SURMOUNT1 and SURMOUNT2 trials, participants received either tirzepatide or a placebo over 72 weeks, aiming for a 500calorie daily deficit and 150 minutes of activity per week.

The 6% difference in weight loss between those with and without diabetes highlights this challenge. Factors like age, weight, and medications like metformin were considered but didn’t fully explain the discrepancy.

Why is it tougher for those with diabetes to lose weight? Insulin resistance, reduced response to weightloss medications, and complications like neuropathy might play a role.

Managing diabetes and obesity is complex. While losing weight helps manage diabetes, it’s often harder and slower. Focus on overall health rather than just numbers on the scale.

Thanks for watching and always remember: small tweaks lead to massive peaks!
Dr. Dan

References:
▪ Antoun G, Nikpay M, McPherson R, Harper ME, Dent R. Is Type 2 Diabetes in Adults Associated With Impaired Capacity for Weight Loss? Can J Diabetes. 2018 Jun;42(3):313316.e1. doi: 10.1016/j.jcjd.2017.06.010. Epub 2017 Aug 8. PMID: 28800932.
▪ Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, Mao H, Zhang S, Ahmad NN, Bunck MC, Benabbad I, Zhang XM; SURMOUNT2 investigators. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT2): a doubleblind, randomised, multicentre, placebocontrolled, phase 3 trial. Lancet. 2023 Aug 19;402(10402):613626. doi: 10.1016/S01406736(23)01200X. Epub 2023 Jun 26. PMID: 37385275.
▪ Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A; SURMOUNT1 Investigators. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022 Jul 21;387(3):205216. doi: 10.1056/NEJMoa2206038. Epub 2022 Jun 4. PMID: 35658024.

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Watch my previous videos about how to fight obesity and about the best medicine for weight loss:

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▪ How to Switch from Ozempic (or Wegovy) to Mounjaro:    • How to Switch from Ozempic (or Wegovy...  

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Disclaimer of Medical Liability. HEALTHCARE EVOLUTION INC. DOES NOT PROVIDE MEDICAL ADVICE. The content of this material is for general informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Reliance on any information provided here is solely at your own risk. Individual medical needs are very different; you should not assume that the information in this document concerning certain courses of treatment or outcomes will apply to you. Rather, you should evaluate your medical condition and make treatment decisions based upon consultation with your physician.

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