When Someone does not experience remission from major depression, we need to ask ourselves why, and come up with new solutions. This discussion will focus on the treatment of these individuals by first explaining what symptoms predict poor response to treatment and what symptoms of major depression result in the most psychosocial dysfunction.

Introduction: 00:00 to 01:40
What Causes Functional Impairment in Depression: 01:41 to 04:07
Cognitive Impairment: 04:08 to 06:27
Anhedonia makes everything worse: 06:28 to 08:49
Emotional Blunting: 08:50 to 11:01
Doctor Vs Patient What’s Important to Treat in Depression: 11:02 to 15:53
loneliness and Depression: 15:54 to 17:43
Conclusion: 17:44 to 20:04

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