As the bloodbrain barrier breaks down, whether as a part of aging or neurodegenerative disease, immune cells, inflammatory cytokines, toxic proteins, and red blood cells gain access to the brain from the blood and contribute to cognitive dysfunction. For example, fibrinogen, a protein involved in blood coagulation and inflammation, can be neurotoxic when it deposits in the brain.

Fibrinogen deposition activates microglial cells leading to neuroinflammation. In animal models, reducing blood fibrinogen levels decreased how much fibrinogen crosses into the brain, reduced white matter damage, and partially restored vascular function and barrier integrity. In this clip, Dr. Axel Montagne describes the dire consequences of a dysfunctional bloodbrain barrier.

Interview published on Feb 28, 2023

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   • Axel Montagne, PhD, on Solving Alzhei...  

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