WWE SmackDown! vs. Raw 2006 is a professional wrestling video game and developed by Yuke's that was released on the PlayStation 2 and PlayStation Portable by THQ in 2005. It is part of the WWE SmackDown vs. Raw video game series based on the professional wrestling promotion World Wrestling Entertainment (WWE), and is the successor to the 2004 game of the same name. SmackDown! vs. Raw 2006 was also the first game in the series to be released on PlayStation Portable.

The main focus of 2006 is to bring more realism and authenticity to the series with many new features, breaking away from the arcadelike gameplay of earlier installments. The game sees the additions of the new Buried Alive and "Fulfill Your Fantasy" matches, and the inclusion of two new modes in General Manager and "CreateAnEntrance".

SmackDown! vs. Raw 2006 went on to become best selling game for the PlayStation 2 console out of the entire series. A steelbook version of the game was released exclusively in Australia. The game was succeeded by WWE SmackDown vs. Raw 2007 in 2006.